Kensler, C. J., Dexter, S. O., and Rhoads, C. P., Cancer Res., 2, 1 (1942).
Lipkin, D., Paul, D. E., Townsend, J., and Weissman, S. I., Science, 117, 534 (1953).
Pullman, A., and Pullman, B., La Cancérisation par les Substances Chimiques et la Structure Moléculaire (Masson, Paris, 1955).
Commoner, B., Townsend, J., and Pake, G. E., Nature, 174, 689 (1954).
Commoner, B., and Ternberg, J. L., Proc. U.S. Nat. Acad. Sci., 47, 1374 (1961). ESR observations of normal and malignant animal tissues at 77° K have been reported by Nebert, D. W., and Mason, H. S., Cancer Res., 23, 833 (1963), and by Swartz, H. M., and Molenda, R. P., Science, 148, 94 (1965). Such frozen samples exhibit ESR signals considerably more complicated than those which we have observed at physiological temperatures. Most of these signals appear to be due to paramagnetic ions. For this reason, and because of saturation effects resulting from the high microwave-power used in such studies, results obtained from frozen tissues are not directly comparable to those obtained from surviving tissues in liquid aqueous systems, such as those reported here.
Commoner, B., Heise, J. J., and Townsend, J., Proc. U.S. Nat. Acad. Sci., 42, 710 (1956).
Rees, K. R., Rowaland, G. F., and Ross, H. F., Biochem. J., 82, 347 (1962).
Miller, J. A., and Miller, E. C., J. Exp. Med., 87, 139 (1948).
Gupta, D. N., J. Path. And Bact., 72, 415 (1956). Fitshugh, O. G., and Nelson, A. A., Science, 108, 626 (1948).
Rees, K. R., and Rowland, G. F., Biochem. J., 80, 428 (1961)
About this article
Cite this article
VITHAYATHIL, A., TERNBERG, J. & COMMONER, B. Changes in Electron Spin Resonance Signals of Rat Liver During Chemical Carcinogenesis. Nature 207, 1246–1249 (1965). https://doi.org/10.1038/2071246a0
Historical origins of the discovery of mammalian nitric oxide (nitrogen monoxide) production/physiology/pathophysiology
Biochemical Pharmacology (2020)
What is the Mechanism of Nitric Oxide Conversion into Nitrosonium Ions Ensuring S-Nitrosating Processes in Living Organisms
Cell Biochemistry and Biophysics (2019)
Transformation of the hydride-containing dinitrosyl iron complex [(NO)2Fe(η2-BH4)]− into [(NO)2Fe(η3-HCS2)]−via reaction with CS2
Dalton Transactions (2019)
Molecular Pharmaceutics (2019)
New agent for nitric oxide (NO) chemotherapy: Synthesis and properties of DNIC with hydrazinium cation in solid phase and solutions
Journal of Molecular Structure (2019)