As reviewed by Fruton1, cathepsins are intracellular proteinases with acid pH optima, ubiquitously found in animal tissues. In the mammal, highest concentrations of cathepsins are found in liver, kidney and spleen2–4. However, perfused rat liver was found to catabolize only 13–15 per cent of the total albumin broken down in the whole animal5.
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HSU, L., TAPPEL, A. Catheptic Activity of the Gastrointestinal Tract, Liver, Spleen and Kidney of the Rat. Nature 207, 1200 (1965). https://doi.org/10.1038/2071200a0
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