Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Phenolic and Indole Amines in the Urine of Schizophrenics

Abstract

THE hypothesis that schizophrenia may be caused by a metabolic abnormality of phenolic or indolic amines has gained supporting experimental results by some research groups, but conflicting results by others. This confused state was reviewed by Kety1, and the contradictory results could be explained by various factors related to different environmental and physical conditions which are secondary to the psychosis. An attempt was made to examine in this laboratory the excretion of various phenolic and indole amines using the subjects under careful control of environmental factors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kety, S., Science, 129, 1528, 1590 (1959).

    Article  ADS  CAS  Google Scholar 

  2. Kakimoto, Y., and Armstrong, M. D., J. Biol. Chem., 237, 208 (1961).

    Google Scholar 

  3. Fernandez, Lagravere, T. A., Vazquez, A. J., and Distefano, A. O., J. Nervous Mental Disease, 133, 441 (1961).

    Article  Google Scholar 

  4. Armstrong, M. D., Shaw, K. N. F., and Wall, P. E., J. Biol. Chem., 218, 293 (1956).

    CAS  PubMed  Google Scholar 

  5. Armstrong, M. D., Shaw, K. N. F., Gortatowski, M. J., and Somger, H., J. Biol. Chem., 232, 17 (1958).

    CAS  PubMed  Google Scholar 

  6. Friedhoff, A. J., and Van Winkle, E., Nature, 194, 897 (1962).

    Article  ADS  CAS  Google Scholar 

  7. Takesada, M., Kakimoto, Y., Sano, I., and Kaneko, Z., Nature, 199, 203 (1963).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

TAKESADA, M., MIYAMOTO, E., KAKIMOTO, Y. et al. Phenolic and Indole Amines in the Urine of Schizophrenics. Nature 207, 1199–1200 (1965). https://doi.org/10.1038/2071199b0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2071199b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing