Changes in Concentration of Polyamines in the Developing Mouse Brain


SPERMIDINE and spermine have recently attracted much interest because of their physical affinity to nucleic acid1–3 and stimulating effect on cell proliferation4–6. These amines occur in high concentrations in actively proliferating tissues such as human semen7, growing chick embryo8, and germinating plant seeds9. These tissues contain a high concentration of deoxyribonucleic acid (DNA). Raina8 has recently found high concentrations of polyamines in the chick embryo which later decreased during incubation. We10 have described the localization of spermine in the cell nucleus using nucleated and non-nucleated blood cells. These findings suggest the importance of polyamines in the growth process of plant and animal tissues.

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  1. 1

    Razin, S., and Rozansky, R., Arch. Biochem. Biophys., 81, 36 (1959).

  2. 2

    Lee Huang, S., and Felsenfeld, G., Nature, 188, 301 (1960).

  3. 3

    Mandel, M., J. Mol. Biol., 5, 435 (1962).

  4. 4

    Herbst, E. J., and Snell, E. E., J. Biol. Chem., 181, 47 (1949).

  5. 5

    Ham, R. G., Biochem. Biophys. Res. Commun., 14, 34 (1964).

  6. 6

    Mager, J., Traub, A., and Grossowicz, N., Nature, 174, 747 (1954).

  7. 7

    Harrison, G. A., Biochem. J., 25, 1885 (1931); 27, 1152 (1933).

  8. 8

    Raina, A., Acta Physiol. Scand., 60, Suppl. 218 (1963).

  9. 9

    Moruzzi, G., and Caldarera, C. M., Arch. Biochem. Biophys., 105, 209 (1964).

  10. 10

    Shimizu, H., Kakimoto, Y., and Sano, I., Arch. Biochem. Biophys., 110, 368 (1965).

  11. 11

    Shimizu, H., Kakimoto, Y., and Sano, I., J. Pharm. Exp. Therap., 143, 199 (1964).

  12. 12

    Schmidt, G., and Thanhauser, S. J., J. Biol. Chem., 161, 83 (1945).

  13. 13

    McIlwain, H., in Biochemistry and the Central Nervous System, second ed., edit. by McIlwain, H., 186 (J. and A. Churchill, London, 1959).

  14. 14

    Folch-Pi, J., in Biochemistry of the Developing Nervous System, edit. by Waelsch, H., 121 (Academic Press, New York, 1955).

  15. 15

    Uzman, L. L., and Rumley, N. K., J. Neurochem., 3, 170 (1958).

  16. 16

    Flexner, J. B., and Flexner, L. B., J. Cell. Comp. Physiol., 38, 1 (1951).

  17. 17

    Palladin, A. V., in Biochemistry of the Developing Nervous System, edit. by Waelsch, H., 177 (Academic Press, New York, 1955).

  18. 18

    Mandel, P., Bleth, R., and Stoll, R., Bull. Soc. Chim. Biol., 31, 1339 (1949).

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SHIMIZU, H., KAKIMOTO, Y. & SANO, I. Changes in Concentration of Polyamines in the Developing Mouse Brain. Nature 207, 1196–1197 (1965).

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