Cathepsin A in Nutritional and Hereditary Muscular Dystrophy


DURING the past few years, several laboratories1–8 have reported that the activities of many of the acid hydrolases of skeletal muscle are greatly increased in wasting diseases from different causes. Although the progressive loss of muscle mass in these conditions is generally attributed primarily to this enhanced activity of the acid hydrolases, there is little direct experimental evidence in support of this hypothesis. Furthermore, other enzymes involved in protein catabolism, such as alkaline protease6 and peptidases9, have been shown to be elevated in dystrophic muscle. The normally low levels of these enzymes in skeletal muscle and the limited knowledge of their substrate specificities have hindered a better understanding of the mechanism of the wasting process.


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IODICE, A., WEINSTOCK, I. Cathepsin A in Nutritional and Hereditary Muscular Dystrophy. Nature 207, 1102 (1965).

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