Cathepsin A in Nutritional and Hereditary Muscular Dystrophy

Abstract

DURING the past few years, several laboratories1–8 have reported that the activities of many of the acid hydrolases of skeletal muscle are greatly increased in wasting diseases from different causes. Although the progressive loss of muscle mass in these conditions is generally attributed primarily to this enhanced activity of the acid hydrolases, there is little direct experimental evidence in support of this hypothesis. Furthermore, other enzymes involved in protein catabolism, such as alkaline protease6 and peptidases9, have been shown to be elevated in dystrophic muscle. The normally low levels of these enzymes in skeletal muscle and the limited knowledge of their substrate specificities have hindered a better understanding of the mechanism of the wasting process.

References

  1. 1

    Weinstock, I. M., Goldrich, A. D., and Milhorat, A. T., Proc. Soc. Exp. Biol. and Med., 88, 257 (1955).

  2. 2

    Weinstock, I. M., Epstein, S., and Milhorat, A. T., Proc. Soc. Exp. Biol. and Med., 99, 272 (1958).

  3. 3

    Zalkin, H., Tappel, A. L., Caldwell, K. A., Shibko, S., Desai, I. D., and Holliday, T. A., J. Biol. Chem., 237, 2678 (1962).

  4. 4

    Tappel, A. L., Zalkin, H., Caldwell, K. A., Desai, I. D., and Shibko, S., Arch. Biochem. Biophys., 96, 340 (1962).

  5. 5

    Pellegrino, C., Villani, G., and Franzini, C., Arch. Sci. Biol. (Bologna), 41, 339 (1957).

  6. 6

    Koszalka, T. R., Mason, K. E., and Krol, G., J. Nutrition, 73, 78 (1961).

  7. 7

    Weinstock, I. M., and Lukacs, M., Proc. Soc. Exp. Biol. and Med., 115, 716 (1964).

  8. 8

    Hajek, J., Gutmann, E., and Sytovy, I., Physiol. Bohemoslov, 13, 32 (1964).

  9. 9

    Weinstock, I. M., Goldrich, A. D., and Milhorat, A. T., Proc. Soc. Exp. Biol. and Med., 91, 302 (1956).

  10. 10

    Iodice, A. A., and Weinstock, I. M., Fed. Proc., 23, 544 (1964).

  11. 11

    Press, E., Porter, R. R., and Cebra, J., Biochem. J., 74, 501 (1960).

  12. 12

    De Duve, C., in Subcellular Particles, 128 (Ronald Press, New York, 1959).

  13. 13

    Fruton, J. S., and Bergmann, M., J. Biol. Chem., 130, 19 (1939).

  14. 14

    Goettsch, M., and Pappenheimer, A. M., J. Exp. Med., 54, 145 (1931).

  15. 15

    Asmundson, V. S., and Julian, L. M., J. Hered., 47, 248 (1956).

  16. 16

    Moore, S., and Stein, W. H., J. Biol. Chem., 211, 907 (1954).

  17. 17

    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

IODICE, A., WEINSTOCK, I. Cathepsin A in Nutritional and Hereditary Muscular Dystrophy. Nature 207, 1102 (1965). https://doi.org/10.1038/2071102a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.