Role of Cysteine in the Production of Fc and F′c Sub-components of γG Myeloma Globulins


RECENTLY, Osserman and Takatsuki1 have described a group of γG myeloma proteins the Fc fragment of which was completely destroyed by the action of papain. A similar protein (myeloma N) was independently examined in this laboratory. This protein was found to be susceptible to papain and trypsin2.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Osserman, E. F., and Takatsuki, K., Science, 145, 499 (1964).

  2. 2

    Poulik, M. D., and Shuster, J., Nature, 204, 577 (1964).

  3. 3

    Ballieux, R. E., Bernier, G. M., Tominaga, K., and Putnam, F. W., Science, 145, 168 (1964).

  4. 4

    Grey, H. M., and Kunkel, H. G., J. Exp. Med., 120, 253 (1964).

  5. 5

    Terry, W. D., and Fahey, J. L., Science, 148, 400 (1964).

  6. 6

    Cebra, J. S., Givol, D., Silman, H. I., and Katchalski, E., J. Biol. Chem., 236, 1720 (1961).

  7. 7

    Hsiao, S. H., and Putnam, F. W., J. Biol. Chem., 263, 122 (1961).

  8. 8

    Schlamovitz, M., Peterson, L. V., and Wissler, F. C., Arch. Biochem. Biophys., 92, 58 (1961).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

POULIK, M., SHUSTER, J. Role of Cysteine in the Production of Fc and F′c Sub-components of γG Myeloma Globulins. Nature 207, 1092–1093 (1965).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.