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Acetylcholinesterase in the Sarcoplasmic Reticulum of Skeletal Muscle

Abstract

IN the region of the end-plate of skeletal muscle a high concentration of acetylcholinesterase (AChE) has been proved by histochemical1–8, as well as by biochemical9,10, methods. There is, however, still disagreement about the localization of the AChE in the ultrastructure of the synapse. Nachmansohn11 and Eccles12 consider the high AChE concentration a prerequisite to the functionally necessary, rapid inactivation of the chemical transmitter acetylcholine (ACh).

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ULBRECHT, G., KRUCKENBERG, P. Acetylcholinesterase in the Sarcoplasmic Reticulum of Skeletal Muscle. Nature 206, 305–306 (1965). https://doi.org/10.1038/206305a0

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