Sensitivity of Passive Haemagglutination for Assay of 7S and 19S Antibodies in Primary Rabbit Anti-bovine Serum Albumin Sera

Abstract

THE formation of macroglobulin (19S) antibodies, in the primary response of various animal species to a variety of antigens, is often followed by an increased synthesis of 7S γ-globulin antibodies. This sequence of antibody synthesis was reported to occur in rabbits following immunization with bovine serum albumin (BSA)1,2. A similar replacement of 19S with 7S anti-BSA antibody was described in chickens3. As a consequence, the anti-protein response in these animals has been interpreted in recent reviews as being similar to the sequential synthesis of antibodies to certain participate antigens, in which early primary antisera consist predominantly of 19S antibodies4–6.

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References

  1. 1

    Bauer, D. C., and Stavitsky, A. B., Proc. U.S. Nat. Acad. Sci., 47, 1667 (1961).

  2. 2

    Benedict, A. A., Brown, R. J., and Ayengar, R., J. Exp. Med., 115, 195 (1962).

  3. 3

    Benedict, A. A., Brown, R. J., and Hersh, R. T., J. Immunol., 90, 399 (1963).

  4. 4

    Fahey, J. L., in Adv. Immunol., 2, 42 (1962).

  5. 5

    Uhr, J. W., Science, 145, 457 (1964).

  6. 6

    Nisonoff, A., and Thorbecke, G. J., Ann. Rev. Biochem., 33 (1964).

  7. 7

    Bauer, D. C., J. Immunol., 91, 323 (1963).

  8. 8

    Boyden, S. V., J. Exp. Med., 93, 107 (1951).

  9. 9

    Benedict, A. A., Hersh, R. T., and Larson, C., J. Immunol., 91, 795 (1963).

  10. 10

    Farr, R. S., J. Infect. Dis., 103, 239 (1958).

  11. 11

    Dreesman, G., Larson, C., Pinckard, R. N., Groyon, R. M., and Benedict, A. A., Proc. Soc. Exp. Biol. and Med., 118, 292 (1965).

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BENEDICT, A. Sensitivity of Passive Haemagglutination for Assay of 7S and 19S Antibodies in Primary Rabbit Anti-bovine Serum Albumin Sera. Nature 206, 1368–1369 (1965) doi:10.1038/2061368b0

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