Sudden Increase of Fat in the Liver of Mice at Birth


DURING late foetal development, the mammalian liver accumulates fat. After birth, changes in fat content seem to differ according to species, and different accounts do not agree. In the guinea-pig, Imrie and Graham1 demonstrated peak amounts of liver fat at the end of prenatal life and gradual decrease of fat after birth. In the rabbit, Stieve and Kaps2 confirmed this by histological methods. In contrast, Malet et al.3 stated, on histochemical grounds, that there was little lipid in the newborn mouse, and an increase around the 18th hour of life.

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  1. 1

    Imrie, C. G., and Graham, S. G., J. Biol. Chem., 44, 243 (1920).

  2. 2

    Stieve, H., and Kaps, U., Z. mikr.-anat. Forsch., 42, 499 (1937).

  3. 3

    Malet, P., Lagarde, R., and Turchini, J. P., C. R. Soc. Biol., Paris, 156, 2058 (1962).

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MORIKAWA, Y., EGUCHI, Y. & HASHIMOTO, Y. Sudden Increase of Fat in the Liver of Mice at Birth. Nature 206, 1368 (1965).

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