Cathartics and the Sodium Pump

Abstract

THE classical concept of the action of the vegetable cathartics is that they irritate the intestinal mucosa. As a result of this ‘irritation’ intestinal motility is increased, and it is assumed that fluid contents are hurried through the intestine so fast that water and electrolytes cannot be absorbed as they are normally because the bowel contents are in contact with the mucosal cells for too short a period of time1–3.

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PHILLIPS, R., LOVE, A., MITCHELL, T. et al. Cathartics and the Sodium Pump. Nature 206, 1367–1368 (1965) doi:10.1038/2061367a0

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