Oxidized and Reduced Pyridine Nucleotides, and Oxidation of the Carbon-1 and Carbon-6 of Glucose, in the Developing Retina

Abstract

THE relative importance of the pentose phosphate route in glucose metabolism by the retina has been studied by a number of laboratories in recent years1–6. Two main approaches have been used in these investigations, one involving in vitro measurements of the differential rates of oxidation of the C-1 and C-6 of glucose, the other dstermining the absolute levels of the oxidized and reduced pyridine nucleotides. Although the evidence obtained in the latter case is less direct, it has the advantage of reflecting more accurately the true in vivo situation. The complications of either procedure are well recognized, however, and the combination of both would appear to be most advantageous in investigations of this type6.

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GRAYMORE, C., TOWLSON, M. Oxidized and Reduced Pyridine Nucleotides, and Oxidation of the Carbon-1 and Carbon-6 of Glucose, in the Developing Retina. Nature 206, 1361–1362 (1965) doi:10.1038/2061361a0

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