Total Optical Resolution of Free α-Amino-acids by the Inoculation Method

Abstract

SEVERAL investigations of the optical resolution of organic compounds by mechanical sorting1,2 and by preferential crystallization3–11 have been reported. This type of simple procedure of optical resolution would be the most advantageous method if we could obtain an optically pure isomer. However, in the reported resolution of DL-amino-acids, most of the methods were impractical or resulted in a partial resolution with the exception of the optical resolution of DL-glutamic acid9 and the copper salt of DL-aspartic acid11.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Pasteur, L., Ann. Chim. Phys. (3), 24, 442 (1848).

  2. 2

    Piutti, A., C.R. Acad. Sci., Paris, 103, 134 (1886).

  3. 3

    Ostromisslensky, I., Ber., 41, 3035 (1908).

  4. 4

    Freudenberg, K., (edit.), Stereochemie, 565 (Franz Deuticke, Leipzig, 1932).

  5. 5

    Read, J., Campbell, I. G. M., and Baker, T. V., J. Chem. Soc., 2305 (1927).

  6. 6

    Puschinsky, R., J. Soc. Chem. Indust., 53, 10 (1934).

  7. 7

    Kögl, F., Hoppe-Seyler's Z. Physiol. Chem., 258, 57 (1939).

  8. 8

    Velluz, L., and Amiard, G., Bull. Soc. Chim. France (5), 20, 342 903 (1953).

  9. 9

    Japanese Patent, 2972 (1956); Chem. Abst., 51, 2135 (1957).

  10. 10

    British Patent 773660, Chem. Abst., 51, 17984; U.S. Patent 2790001, Chem. Abst., 51, 13910.

  11. 11

    Harada, K., and Fox, S. W., Nature, 194, 768 (1962).

  12. 12

    Oparin, A. I., The Origin of Life on the Earth, third ed., Synge, A., trans. (Oliver and Boyd, London, 1957).

  13. 13

    Fox, S. W., (edit.), The Origin of Prebiological Systems and of Their Molecular Matrices (Academic Press, New York, 1964).

  14. 14

    Fox, S. W., Johnson, J. E., and Vegotsky, A., Science, 124, 923 (1956).

  15. 15

    Wald, G., Ann. N.Y. Acad. Sci., 69, 352 (1957).

  16. 16

    Harada, K., Protein, Nucleic Acid, Enzyme (Tokyo), 6, 65 (1961).

  17. 17

    Urey, H. C., The Planets (Yale University Press, New Haven, Connecticut, 1952).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HARADA, K. Total Optical Resolution of Free α-Amino-acids by the Inoculation Method. Nature 206, 1354–1355 (1965) doi:10.1038/2061354a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.