Autoradiographic Evaluation of the Distribution of N,N′-bis(Thiazole)-2,7- fluorene-disulphonamide-35S in Organs of Rats

Abstract

DETERMINATION of the diagnostic value of N,N′-bis (thiazole)-2,7-fluorene-disulphonamide-35S (TFDS-35) revealed some differences in its distribution in the tissues of rats bearing Walker carcinosarcoma as compared with tumour-free animals, regarding the TFDS-35 level in red blood cells, blood plasma, liver, spleen, kidneys and urine1. Furthermore, the tumour tissue showed a relatively high concentration of the disulphonamide. The present investigation was aimed at explaining these differences by histological and autoradiographic examination of selected organs and tumour tissue of rats.

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KASPRZAK, K., MALEJKA, D. & GABRYEL, P. Autoradiographic Evaluation of the Distribution of N,N′-bis(Thiazole)-2,7- fluorene-disulphonamide-35S in Organs of Rats. Nature 206, 1266–1267 (1965) doi:10.1038/2061266a0

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