Conjugation of Aldosterone by Bovine and Mouse Liver and Kidney

Abstract

PREVIOUS in vivo experiments in man have shown that the formation of water-soluble conjugates of aldosterone is a very important part of its metabolism1. These investigators have also demonstrated the presence of a urinary conjugate of aldosterone which is split by mild acid hydrolysis and which has been designated the ‘3-oxo-conjugate’1. In addition, the discovery of urinary tetrahydro aldosterone and glucuronide conjugates of this compound reveals that glucuronides of aldosterone are of great importance in the metabolism of this compound2–4.

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References

  1. 1

    Ayres, P. J., Barlow, J., Garrod, O., Kellie, A. E., Tait, J. F., Tait, S. A. S., and Walker, G., in International Symposium on Aldosterone, edit. by Muller and O'Connor (London, 1958).

  2. 2

    Pasqualini, J. R., and Jayle, M. F., Nature, 198, 1095 (1963).

  3. 3

    Ulick, S., and Lieberman, S., J. Amer. Chem. Soc., 79, 6567 (1957).

  4. 4

    Flood, C., Layne, D. S., Ramclaran, S., Rossipal, E., Tait, J. F., and Tait, S. A. S., Acta Endocrin. (Kbh.), 36, 237 (1961).

  5. 5

    Chart, J. J., Gordon, E. G., Helmer, P., and LeSher, M., J. Clin. Invest., 35, 254 (1956).

  6. 6

    Berliner, D. L., and Dougherty, T. F., Pharmacol. Rev., 13, 329 (1961).

  7. 7

    Sandor, T., and Lanthier, A., Acta Endocrin., 39, 81 (1962).

  8. 8

    Stevens, W., Berliner, D. L., and Dougherty, T. F., Endocrinology, 68, 875 (1961).

  9. 9

    Stevens, W., and Berliner, D. L., Rad. Res., 20, 510 (1963).

  10. 10

    Pechet, M. M., Hesse, R. H., and Kohler, H., J. Amer. Chem. Soc., 82, 5251 (1960).

  11. 11

    Berliner, D. L., Stevens, W., and Dougherty, T. F., Proc. Soc. Exp. Biol. and Med., 110, 268 (1962).

  12. 12

    Cohn, G. L., Hume, M., and Bondy, P. K., Abstr. 366, First Int. Cong. Endocrin., Copenhagen (1960).

  13. 13

    Stevens, W. (personal communication).

  14. 14

    Berliner, D. L., Nabors, C. J., and Dougherty, T. F., J. Reticuloendothelial Soc., 1, 1 (1964).

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PANAGIOTIS, N., BERLINER, D. Conjugation of Aldosterone by Bovine and Mouse Liver and Kidney. Nature 206, 1262–1263 (1965) doi:10.1038/2061262a0

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