Conjugation of Aldosterone by Bovine and Mouse Liver and Kidney


PREVIOUS in vivo experiments in man have shown that the formation of water-soluble conjugates of aldosterone is a very important part of its metabolism1. These investigators have also demonstrated the presence of a urinary conjugate of aldosterone which is split by mild acid hydrolysis and which has been designated the ‘3-oxo-conjugate’1. In addition, the discovery of urinary tetrahydro aldosterone and glucuronide conjugates of this compound reveals that glucuronides of aldosterone are of great importance in the metabolism of this compound2–4.

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PANAGIOTIS, N., BERLINER, D. Conjugation of Aldosterone by Bovine and Mouse Liver and Kidney. Nature 206, 1262–1263 (1965) doi:10.1038/2061262a0

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