Dimethylnitrosamine; its Hepatotoxic Effect in Sheep and its Occurrence in Toxic Batches of Herring Meal

Abstract

DURING the years 1961 and 1962 there were in Norway outbreaks of toxic hepatosis in ruminants, giving rather characteristic symptoms and liver lesions1,2. Experiments indicated a possible connexion between the disease and the feeding of meal made from herring preserved with sodium nitrite3. As the hepatotoxic properties of dimethyl-nitrosamine have been established for several species4,5, we decided to investigate the toxicity of this compound to sheep, and its possible occurrence in herring meal.

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References

  1. 1

    Hausen, M. Aas, Nord. Vet.-Med., 16, 323 (1964).

  2. 2

    Koppang, N., Nord. Vet.-Med., 16, 305 (1964).

  3. 3

    Koppang, N., Slagsvold, P., Hansen, M. Aas, Sögnen, E., and Svenkerud, R., Nord. Vet.-Med., 16, 343 (1964).

  4. 4

    Barnes, J. M., and Magee, P. M., Brit. J. Industr. Med., 11, 167 (1954).

  5. 5

    Jacobson, K. H., Wheelwright, jun., H. J., Clem, J. H., and Shannon, R. N., Arch. Industr. Health, 12, 617 (1955).

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SAKSHAUG, J., SÖGNEN, E., HANSEN, M. et al. Dimethylnitrosamine; its Hepatotoxic Effect in Sheep and its Occurrence in Toxic Batches of Herring Meal. Nature 206, 1261–1262 (1965) doi:10.1038/2061261b0

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