Pharmacology of Experimental Tremor

Abstract

TREMORINE (1-4 dipyrolidine-2-butyn (T)) has stimulated an interest in an experimental pharmacology because it is the first substance which can definitely produce rest tremor, rigor and akinesia, that is, the symptoms of Parkinson's disease1. Further, the symptoms produced in tremorine-induced tremor (TT) can be relieved with all known, anti-Parkinson substances and drugs inhibiting the cholinergic nervous system. Recently, Cho and Jendon2 found that symptoms produced with (T) or with oxotremorin (oxo-T), an active principle of T, can be removed with an analogue of T, 1-4-bis(N-hexamethylenimino)-2-butyn (anti-T). T itself is the most specific substance. Everett1 states that among many similar derivatives only T produces tremor.

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References

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STERN, P., RADOVIĆ, N. & BULJUBAŠIĆ, S. Pharmacology of Experimental Tremor. Nature 206, 1261 (1965) doi:10.1038/2061261a0

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