Iodine Effects on Thyroid Function in Sporadic Goitrous Cretinism

Abstract

WE have found that the short-term administration of pharmacological doses of thyroactive substances (90 mg triiodothyroacetic acid or equivalent amounts of desiccated thyroid within 9 days) produced in three sibs with sporadic goitrous cretinism prolonged clinical remissions with normalization of thyroid function persisting in two patients for 8–10 months and in the third for so far 5 years and 9 months1–6. The primary purpose of the investigation recorded here was to determine whether in the conditions of our ‘stosstherapy’ thyroid hormone acted as a whole, or whether it merely served as a vehicle for iodine as suggested by Saunders and Stark7 and Galton and Ingbar8.

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ZONDEK, H., LESZYNSKY, H. Iodine Effects on Thyroid Function in Sporadic Goitrous Cretinism. Nature 206, 1258–1259 (1965). https://doi.org/10.1038/2061258a0

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