Abstract
TRYPTAMINE is a normal constituent of human urine1–5; about 30–120 µg of the amine are excreted per 24 h. In blood, tryptamine has hitherto been demonstrated only qualitatively and under pathological conditions in a carcinoid patient6. There is no information about an occurrence of N,N-dimethyltryptamine in human beings. N,N-dimethyl-5-hydroxytryptamine (= Bufotenin) was demonstrated qualitatively as a constituent of normal human urine4,7; in children an excretion of 0–0.03 µg amine/100 mg creatinine has been found with, at most, semi-quantitative methods4. Apparently, N,N-dimethyl-5-hydroxytryptamine was still not demonstrated in blood. 5-Methoxytryptamine has been found in the urine of patients with rheumatic fever8, and that in an order of magnitude of 30–210 µg/24 h.
References
Rodnight, R., Biochem. J., 64, 621 (1956).
Sjoerdsma, A., Oates, J. A., Zaltzman, P., and Udenfriend, S., J. Pharmacol. Exp. Therap., 126, 217 (1959).
Levine, R. J., Oates, J. A., Vendsalu, A., and Sjoerdsma, A., J. Clin. Endocrinol. Metabol., 22, 1242 (1962).
Perry, Th. L., Shaw, K. N. F., Walker, D., and Redlich, D., Pediatrics, 30, 576 (1962).
Perry, Th. L., Science, 139, 587 (1963).
Eccleston, D., Crawford, T. B. B., and Ashcroft, G. W., Nature, 197, 502 (1963).
Bumpus, F. M., and Page, I. H., J. Biol. Chem., 212, 111 (1955).
Haddox, Jun., Ch. H., and Saslaw, M. S., J. Clin. Invest., 42, 435 (1963).
Gross, H., and Franzen, Fr., Biochem. Z., 340, 403 (1964).
Gross, H., and Franzen, Fr., Biochem. Z. (in the press).
Gross, H., and Franzen, Fr., Biochem. Z. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FRANZEN, F., Gross, H. Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine. Nature 206, 1052 (1965). https://doi.org/10.1038/2061052a0
Issue Date:
DOI: https://doi.org/10.1038/2061052a0
This article is cited by
-
Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats
Scientific Reports (2023)
-
N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
Translational Psychiatry (2020)
-
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
Scientific Reports (2019)
-
The hallucinogenic world of tryptamines: an updated review
Archives of Toxicology (2015)
-
Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter
Journal of Neural Transmission (2009)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
