Letter | Published:

Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine

Naturevolume 206page1052 (1965) | Download Citation



TRYPTAMINE is a normal constituent of human urine1–5; about 30–120 µg of the amine are excreted per 24 h. In blood, tryptamine has hitherto been demonstrated only qualitatively and under pathological conditions in a carcinoid patient6. There is no information about an occurrence of N,N-dimethyltryptamine in human beings. N,N-dimethyl-5-hydroxytryptamine (= Bufotenin) was demonstrated qualitatively as a constituent of normal human urine4,7; in children an excretion of 0–0.03 µg amine/100 mg creatinine has been found with, at most, semi-quantitative methods4. Apparently, N,N-dimethyl-5-hydroxytryptamine was still not demonstrated in blood. 5-Methoxytryptamine has been found in the urine of patients with rheumatic fever8, and that in an order of magnitude of 30–210 µg/24 h.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Rodnight, R., Biochem. J., 64, 621 (1956).

  2. 2

    Sjoerdsma, A., Oates, J. A., Zaltzman, P., and Udenfriend, S., J. Pharmacol. Exp. Therap., 126, 217 (1959).

  3. 3

    Levine, R. J., Oates, J. A., Vendsalu, A., and Sjoerdsma, A., J. Clin. Endocrinol. Metabol., 22, 1242 (1962).

  4. 4

    Perry, Th. L., Shaw, K. N. F., Walker, D., and Redlich, D., Pediatrics, 30, 576 (1962).

  5. 5

    Perry, Th. L., Science, 139, 587 (1963).

  6. 6

    Eccleston, D., Crawford, T. B. B., and Ashcroft, G. W., Nature, 197, 502 (1963).

  7. 7

    Bumpus, F. M., and Page, I. H., J. Biol. Chem., 212, 111 (1955).

  8. 8

    Haddox, Jun., Ch. H., and Saslaw, M. S., J. Clin. Invest., 42, 435 (1963).

  9. 9

    Gross, H., and Franzen, Fr., Biochem. Z., 340, 403 (1964).

  10. 10

    Gross, H., and Franzen, Fr., Biochem. Z. (in the press).

  11. 11

    Gross, H., and Franzen, Fr., Biochem. Z. (in the press).

Download references

Author information


  1. 5 Köln-Marienburg, Ulmenallee, 3

    •  & H. Gross


  1. Search for FR. FRANZEN in:

  2. Search for H. Gross in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.