Effect of Glucose on Fatty Acid Uptake and Oxidation by Bone Marrow Cells from Guinea-pigs


IN their investigations of the fat composition and in vitro oxygen consumption of marrow from fed and fasted rabbits, Evans et al.1 observed a respiratory quotient of 0.85 for marrow cell suspensions incubated in the absence of glucose but in the presence of all the fatty material of whole marrow. The authors were unable to detect any uptake of fatty acid by the marrow cells and concluded that saturated fats were probably not degraded in the marrow for the production of local energy. In the work recorded here we have re-examined the question of in vitro uptake and oxidation of fatty acid by bone marrow cells. Our results indicate that fatty acid is taken up and oxidized by washed bone marrow cells suspended in a medium containing 5 per cent albumin as a carrier for fatty acid. Furthermore, we have found that glucose exerts a considerable influence on the rate of uptake and oxidation of fatty acid.

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  1. 1

    Evans, J. D., Riemenschneider, R. W., and Herb, S. F., Arch. Biochem. Biophys., 53, 157 (1954).

  2. 2

    Goodman, DeW. S., Science, 125, 1296 (1957).

  3. 3

    Evans, W. H., and Mueller, P. S., J. Lipid Res., 4, 39 (1963).

  4. 4

    Eaton, P., and Steinberg, D., J. Lipid Res., 2, 376 (1961).

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EVANS, W., MUELLER, P. Effect of Glucose on Fatty Acid Uptake and Oxidation by Bone Marrow Cells from Guinea-pigs. Nature 206, 1041 (1965) doi:10.1038/2061041a0

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