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Role of Splenomegaly in Tumour-bearing Mice


MANY attempts have been made to explain the presence of splenomegaly in tumour-bearing mice. Early work by Andreini1 et al., in mice bearing homografted tumours, demonstrated splenomegaly which was interpreted as evidence of immunological activity against the tumour. When splenomegaly was found in the isologous situation the interpretation was made again2 that this was a sign of a response of the mouse to a cancer-specific antigen in the tumour and this antigen might be lost on transplantation. Stuart and El Hassan3 have recently shown the protective effect of isologous spleen cells from tumour-bearing mice with splenomegaly, injected locally with the Landschütz ascites tumour. In the experiments reported here I have attempted to demonstrate the protective influence of the splenomegaly by transferring spleen cell suspensions from tumour-bearing mice to isologous mice challenged with the same tumour.

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MACKAY, W. Role of Splenomegaly in Tumour-bearing Mice. Nature 205, 918–919 (1965).

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