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Changes in Sino-atrial Node Transmembrane Potentials on Vagal Stimulation of the Isolated Rabbit Atrium

Nature volume 205, pages 808–809 (1965)Cite this article

Abstract

Hutter and Trautwein1 reported that vagal stimulation results in hyperpolarization, complete disappearance of action potentials, and a shortening of duration of the post-stimulation pacemaker potentials of the frog sinus venosus. No report has appeared regarding the effects of stimulation of external vagal fibres on sino-atrial (S-A) node action potentials of mammalian heart. In the experiments described here, we set out to test the responses of the various types of S-A node fibres2 to vagal stimulation of isolated rabbit atria.

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References

  1. Hutter, O. F., and Trautwein, W., Nature, 176, 512 (1955).

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  2. De Carvalho, A. P., De Mello, W. C., and Hoffman, B. F., Amer. J. Physiol., 196, 483 (1959).

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  3. Toda, N., Fujiwara, M., and Shimamoto, K., Jap. J. Pharmacol., 14, 118 (1964).

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of Washington, Seattle

    NOBORU TODA & THEODORE C. WEST

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  1. NOBORU TODA
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  2. THEODORE C. WEST
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TODA, N., WEST, T. Changes in Sino-atrial Node Transmembrane Potentials on Vagal Stimulation of the Isolated Rabbit Atrium. Nature 205, 808–809 (1965). https://doi.org/10.1038/205808a0

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