Abstract
IT is believed that muscle contracts or relaxes depending on the concentration of calcium in the sarcoplasm: when the concentration rises to some required level the muscle contracts; when it falls below this level the muscle relaxes1–4. The sarcoplasmic reticulum, which can take up calcium actively, seems to play a major part in controlling the level of calcium available to the contractile protein5–7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Heilbrunn, L. V., and Wiercinski, F. J., J. Cell. Comp. Physiol., 29, 15 (1957).
Niedergerke, R., J. Physiol., 128, 12P (1955).
Podolsky, R. J., and Hubert, C. E., Fed. Proc., 20, 301 (1961).
Portzehl, H., Caldwell, P. C., and Ruegg, J. C., Biochim. Biophys. Acta, 79, 581 (1964).
Ebashi, S., Arch. Biochem. Biophys., 76, 410 (1958).
Hasselbach, W., and Makinose, M., Biochem. Z., 333, 519 (1961).
Ebashi, S., and Lipmann, F., J. Cell. Biol., 14, 389 (1962).
Szent-Györgyi, A., Chemistry of Muscular Contraction (Academic Press, New York, 1951).
Weber, A., and Hertz, R., Biochem. Biophys. Res. Comm., 6, 364 (1961).
Weber, A., and Hertz, R., J. Biol. Chem., 238, 599 (1963).
Ebashi, S., J. Biochem., 50, 236 (1961).
Levy, H. M., and Fleisher, M., Biochim. Biophys. Acta (in the press).
Morales, M. F., and Hotta, K., J. Biol. Chem., 235, 1979 (1960).
Blum, J. J., Arch. Biochem. Biophys., 87, 104 (1960).
Murayama, K., and Gergely, J., J. Biol. Chem., 237, 1100 (1962).
Bendall, J. R., J. Physiol., 121, 232 (1953).
Ebashi, S., Nature, 200, 1010 (1963).
Ebashi, S., and Ebashi, F., Nature, 203, 646 (1964).
Bendall, J. R., and Davey, C. L., Biochim. Biophys. Acta, 26, 93 (1957).
Tonomura, Y., and Yoshimura, J., Arch. Biochem. Biophys., 90, 73 (1960).
Hasselbach, W., Z. Naturforsch., 7b, 163 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LEVY, H., RYAN, E. Evidence that Calcium activates the Contraction of Actomyosin by overcoming Substrate Inhibition. Nature 205, 703–705 (1965). https://doi.org/10.1038/205703b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/205703b0
This article is cited by
-
Natural tropomyosin as a physiological inhibitor of the contractile activity of actomyosin
Pfl�gers Archiv European Journal of Physiology (1970)
-
Muscle Contraction produced by Sulphydryl Inhibitors
Nature (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.