Oestrogen and Gonadotrophin in the Blood of Dogs during Bone Fracture Healing

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Abstract

PREVIOUS reports have dealt with variations in the activity of thyroid glands1 and changes in the levels of androgens, follicle-stimulating and luteinizing hormones2 as a result of bone fracture. The present investigation is concerned with changes in oestrogens and gonadotrophic hormones (FSH and LH) in the blood of dogs during the healing of bone fractures. Twenty-five mature anoestrous non-pregnant female dogs were used. Mid-diaphyseal fractures of the left radius were made by an open technique. Animals were anaesthetized using chloropromazine hydrochloride and thiopental sodium. The radius in the dog was firmly fixed at its proximal and distal extremities to the ulna, which was left intact and acted as a natural splint.

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SAID, A., SOLIMAN, F. Oestrogen and Gonadotrophin in the Blood of Dogs during Bone Fracture Healing. Nature 205, 605 (1965) doi:10.1038/205605a0

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