Abstract
DESFERRIOXAMINE B is a specific iron complexing agent originally obtained from an iron-bearing metabolite of Actinomycetes (Streptomyces pilosus)1,2. It is available for clinical use as ‘Desferal’* (desferrioxamine B methanesulphonate) and has undergone extensive evaluation in the treatment of chronic iron overload states3. The compound, a trihydroxamic acid derivative, has a strong affinity for ferric ions (stability constant log K = 30.6) with which it reacts to form a complex known as ferrioxamine, but it is reported to form relatively little complex with ferrous ions4. During the course of investigations involving the use of desferrioxamine B in the treatment of acute iron poisoning in dogs5, it was necessary to determine the extent to which ferrous ions form a complex with the chelate. In this communication we wish to present preliminary results relative to the ability of desferrioxamine B to complex with ferrous iron.
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GOODWIN, J., WHITTEN, C. Chelation of Ferrous Sulphate Solutions by Desferrioxamine B. Nature 205, 281–283 (1965). https://doi.org/10.1038/205281b0
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DOI: https://doi.org/10.1038/205281b0
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