Abstract
IN Thailand in 1952 Virginia Minnich and her colleagues first discovered inclusion bodies in the red cells of patients with thalassæmia-like syndrome1. This disease became known here as inclusion-body anæmia, but was later identified as thalassæmia-Hgb H disease, first reported by Rigas et al.2. Its genetical peculiarity was immediately recognized. In the majority of cases the abnormal pigment is not detected in either parent, or in the progeny. Thalassæmia stigmata are always present in one of the parents and in the patients themselves, and in some of the sibs and progeny. The associated thalassæmia is of the normal Hgb A2 or alpha type.
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References
Minnich, V., Na-Nakorn, S., Chongchareonsuk, S., and Kochaseni, S., Blood, 9, 1 (1954).
Rigas, D. A., Koler, R. D., and Osgood, E. E., Science, 121, 372 (1955).
Motulsky, A. G., Nature, 178, 1055 (1956).
Jones, R. T., Schroeder, W. A., Balog, J. E., and Vinograd, J. R., J. Amer. Chem. Soc., 81, 3161 (1959).
Ingram, V. M., and Stretton, A. A. W., Nature, 184, 1903 (1959).
Ramot, B., Sheba, Ch., Fisher, S., Ager, J. A. M., and Lehmann, H., Brit. Med. J., ii, 1228 (1959).
Huehns, E. R., Flynn, F. V., Butler, E. A., and Shooter, E. M., Brit. J. Haemat., 6, 388 (1960).
Dance, N., Huehns, E. R., and Beaven, G. H., Biochem. J., 87, 240 (1963).
Koler, R. D., and Rigas, D. A., Ann. Hum. Genet., 25, 95 (1961).
Na-Nakorn, S., Wasi, P., and Suingdumrong, A., Third Asian and Pacific Congress in Hæmatology, Jerusalem, August 17–22, 1964.
Minnich, V., Cordonier, J. K., Williams, W. J., and Moore, C. V., Blood, 19, 137 (1962).
Weatherall, D. J., Brit. J. Hæmat., 9, 263 (1963).
Lie-Injo, L. E., Lie, H. G., Ager, J. A. M., and Lehmann, H., Brit. J. Hæmat., 8, 1 (1962).
Tuchinda, S., et al., unpublished data.
Na-Nakorn, S., Minnich, V., and Chernoff, A. I., J. Lab. Clin. Med., 47, 490 (1956).
Lie-Injo, L. E., and De V. Hart, P. L., Acta Hæmat. (Basel), 29, 358 (1963).
Beaven, G. H., Stevens, B. L., Dance, N., and White, J. C., Nature, 199, 1297 (1963).
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WASI, P., NA-NAKORN, S. & SUINGDUMRONG, A. Hæmoglobin H Disease in Thailand: a Genetical Study. Nature 204, 907–908 (1964). https://doi.org/10.1038/204907a0
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DOI: https://doi.org/10.1038/204907a0
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