Letter | Published:

Prevention of Cerebral Œdema induced by Triethyltin in Rabbits by Cortico-steroids



PATIENTS receiving cortico-steroid therapy who underwent craniotomy were observed to have a smoother post-operative course than would have been expected1. Surgeons were thus led deliberately to administer cortico-steroid preparations before and after craniotomy, in order to ease the patient's course. In particular, patients diagnosed as having cerebral œdema, either from a tumour or more diffuse cause, seemed to benefit2, and the improvement is explained on the assumption that this treatment reduces the cerebral œdema. The most recent preparation used has been dexamethasone since it is supposed to have minimal water- and sodium-retaining properties.


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    Lippert, R. G., Svien, H. J., Grindlay, J. H., Goldstein, N. P., and Gastineau, C. F., J. Neurosurg., 17, 583 (1960).

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