Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Lowering Effect of Neostigmine on Plasma Free Fatty Acids

Nature volume 204, pages 888–889 (1964)Cite this article

Abstract

THE actions of a number of drugs provide evidence that the sympathetic nervous system functions in the mobilization of free fatty acids. Epinephrine, norepinephrine and isoproterenol cause an elevation of free fatty acid levels whereas blocking drugs such as dichloroisoproterenol1, pronethalol2 and N-isopropyl methoxamine3,4 have been reported to block the elevation of free fatty acid due to injection of one or more of these sympathomimetic substances. The present communication describes the ability of another type of agent, the cholinesterase inhibitor neostigmine methylsulphate, to lower fasting levels of plasma free fatty acid in the conscious dog and to antagonize the epinephrine-induced release of free fatty acid from the rat epididymal fat pad in vitro.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Mayer, S., Moran, N. C., and Fain, J., J. Pharmacol. Exp. Therap., 134, 18 (1961).

    CAS  Google Scholar 

  2. Pilkington, T. R. E., Lowe, R. D., Robinson, B. F., and Titterington, E., Lancet, ii, 316 (1962).

  3. Burns, J. J., Colville, K. I., Lindsay, L. A., and Salvador, R. A., J. Pharmacol. Exp. Therap., 114, 163 (1964).

    Google Scholar 

  4. Salvador, R. A., Colville, K. I., April, S. A., and Burns, J. J., J. Pharmacol. Exp. Therap., 114, 172 (1964).

    Google Scholar 

  5. Dole, V. P., J. Clin. Invest., 35, 150 (1956).

    Article  CAS  Google Scholar 

  6. Riker, jun., W. F., and Wescoe, W. C., J. Pharmacol. Exp. Therap., 88, 58 (1946).

    CAS  Google Scholar 

  7. Salvador, R. A., and Kuntzman, R., The Pharmacologist (in the press).

Download references

Author information

Authors and Affiliations

  1. Wellcome Research Laboratories, Burroughs Wellcome and Co. (U.S.A.), Inc., Tuckahoe, New York

    K. I. COLVILLE, R. A. SALVADOR, L. A. LINDSAY & J. J. BURNS

Authors
  1. K. I. COLVILLE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. SALVADOR
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. A. LINDSAY
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. J. BURNS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

COLVILLE, K., SALVADOR, R., LINDSAY, L. et al. Lowering Effect of Neostigmine on Plasma Free Fatty Acids. Nature 204, 888–889 (1964). https://doi.org/10.1038/204888b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/204888b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing