Letter | Published:

Lactic Dehydrogenase Isozymes and Ageing of Erythrocytes



DURING the life span of erythrocytes several of their enzymes undergo some modification1–3. Lactic dehydrogenase (LDH) is of special interest, because of the knowledge we have of its isozyme composition4,5. To investigate whether ageing affects each isozyme to the same degree, the electrophoretic pattern of LDH isozymes of young and old red cells were compared.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Marks, P. A., Johnson, A. B., and Hirshberg, E., Proc. U.S. Nat. Acad. Sci., 44, 529 (1958).

  2. 2

    Schapira, F., Rev. Franc. Et. Clin. biol., 4, 151 (1959).

  3. 3

    Marks, P. A., Nouv. Rev. Franc. Hematologie, 1, 900 (1961).

  4. 4

    Vesell, E. S., and Bearn, A. G., Proc. Soc. Exp. Biol. and Med., 94, 96 (1957).

  5. 5

    Vesell, E. S., and Bearn, A. G., J. Gen. Physiol., 45, 553 (1962).

  6. 6

    Rosa, J., Schapira, G., and Dreyfus, J. C., Bull. Soc. Chim. Biol., 43, 555 (1961).

  7. 7

    Smithies, O., Biochem. J., 61, 629 (1955).

  8. 8

    Markert, C. L., and Moller, F., Proc. U.S. Nat. Acad. Sci., 45, 753 (1959).

  9. 9

    Nachlas, M. M., Margulies, S. I., Goldberg, J. B., and Seligman, A. M., Anal. Biochem., 1, 317 (1960).

  10. 10

    Cahn, R. D., Kaplan, N. O., Levine, L., and Zwilling, E., Science, 136, 962 (1962).

Download references

Author information

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.

About this article

Publication history

  • Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.