Letter | Published:

Patterns of Interferon Appearance in Mice injected with Bacteria or Bacterial Endotoxin

Nature volume 204, page 712 (14 November 1964) | Download Citation

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Abstract

PREVIOUS work1 has shown that the intravenous injection of large numbers of live Brucella abortus into chickens results in the appearance in the serum of a viral inhibitor with the properties of interferon. Inhibitor reached maximum levels about 12 h after inoculation. It was also reported that large numbers of Newcastle disease virus (NDV) particles produced maximum levels of interferon in chickens about 12 h after intravenous inoculation. Injection of large doses of other gram-positive and -negative bacteria or bacterial endotoxins failed to produce demonstrable inhibitors in the circulation of chickens at 6–8 h.

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References

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  1. Department of Microbiology, University of Pittsburgh, School of Medicine, Pittsburgh.

    • WARREN R. STINEBRING
    •  & JULIUS S. YOUNGNER

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https://doi.org/10.1038/204712a0

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