Letter | Published:

Oxygen Equilibria of Red Cell Hæmolysates of Adult Individuals, Heterozygous for Different Rare Abnormal Hæmoglobins

Nature volume 204, page 701 (14 November 1964) | Download Citation

Subjects

Abstract

IN the past few years, oxygen equilibria of various normal and abnormal adult human hæmoglobin types have been studied. No differences were observed between normal Hb-A (&α2β2) and the β-chain abnormalities Hb-S (ref. 1), Hb-C (ref. 2) and Hb-E (ref. 3). Investigations of the isolated Hb-A2′ (α2δ2) and its abnormal variant Hb-A2 revealed a considerable increase in oxygen affinity when compared with normal Hb-A (ref. 4). Hb-Lepore, which is composed of normal α-chains and ‘β’ chains being related to the β-chain of Hb-A as well as to the δ-chain of Hb-A2 (ref. 5), showed a high affinity for molecular oxygen similar to that of Hb-A2 (ref. 1). The affinities of the α-chain lacking abnormal hæmoglobin types Hb-H (β4) and Hb-Bart's (γ4) for molecular oxygen were found to be extremely high, while no Bohr effect or hæm–hæm interactions were detectable6,7.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , and , Biochim. Biophys. Acta 74, 69 (1963).

  2. 2.

    , New England J. Med., 253, 322 (1955).

  3. 3.

    (personal communication, 1962).

  4. 4.

    , , , and , Nature, 195, 1109 (1962).

  5. 5.

    , Proc. U.S. Nat. Acad. Sci., 48, 1800 (1962).

  6. 6.

    , , , and , J. Biol. Chem., 236, 2926 (1961).

  7. 7.

    , , , , , and , Blood, 20, 302 (1962).

  8. 8.

    , and , Clin. Chim. Acta, 5, 102 (1960).

  9. 9.

    , and , J. Chromatog., 7, 180 (1962).

  10. 10.

    , , , and , Clin. Chim. Acta, 6, 677 (1961).

  11. 11.

    , Adv. Clin. Chem. (in the press).

  12. 12.

    , and , Biochim. Biophys. Acta, 53, 569 (1961).

  13. 13.

    , Nature, 196, 276 (1962).

  14. 14.

    , and , Nature, 193, 489 (1962).

  15. 15.

    , J. Physiol., 40, 4 (1910).

Download references

Author information

Affiliations

  1. Department of Biochemistry, Medical College of Georgia, Augusta.

    • T. H. J. HUISMAN
    •  & J. M. SCHILLHORN VAN VEEN

Authors

  1. Search for T. H. J. HUISMAN in:

  2. Search for J. M. SCHILLHORN VAN VEEN in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/204701a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.