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Inhibition of ADP-induced Platelet Aggregation by Substituted Amino-acids

Nature volume 204, pages 698700 (14 November 1964) | Download Citation

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Abstract

AGGREGATION of platelets in the presence of adenosine diphosphate (ADP) appears to be important in hæmostasis and in the genesis of platelet thrombosis. There is evidence that this reaction is common to platelet clumping induced by a variety of stimuli, including collagen, adrenaline, long-chain fatty acids, and perhaps weak solutions of thrombin. Although this phenomenon is under investigation in many laboratories, the mechanism by which ADP causes platelet aggregation is largely unknown. Certain inhibitors of platelet clumping have been described (for example, inhibition of thrombin-induced platelet aggregation by heparin1 or of ADP by adenosine2), and investigation of the inhibitory reaction has afforded some insight into the underlying process.

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Affiliations

  1. Massachusetts General Hospital, Boston, Mass.

    • E. W. SALZMAN
    •  & D. A. CHAMBERS

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https://doi.org/10.1038/204698b0

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