Letter | Published:

Effect of Methylamphetamine on the Psychomotor Depression produced by Adrenaline in Mice

Nature volume 204, pages 695696 (14 November 1964) | Download Citation



INTRAPERITONEAL injections of catecholamines produce a marked depression of the psychomotor activity of mice, accompanied by vegetative phenomena, such as tachycardia, exophthalmos and pilo-erection. These vegetative phenomena are, however, independent of the psychomotor depression, for they can be suppressed by phentolamine (‘Regitin R’), an adrenergic blocking agent, without modifying the depressed behaviour. Furthermore, isopropylarterenol produced, in higher doses, a similar psychomotor depression, without vegetative symptoms1.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    , and , Nature, 193, 590 (1962).

  2. 2.

    , Pharmacol. Rev., 11, 794 (1959).

Download references

Author information


  1. Laboratorio de Psicofarmacología y Neuropsiquiatría Experimental, Hospital Nacional de Neuropsiquiatría (H), Instituto Nacional de Salud Mental and Cátedra de Psiquiatría, Facultad de Ciencias Médicas, Universidad Nacional de Buenos Aires, Vieytes 375, Buenos Aires, Argentina.

    • E. FISCHER
    • , R. L. LUDMER
    •  & S. R. KRUGLIKOFF


  1. Search for E. FISCHER in:

  2. Search for R. L. LUDMER in:

  3. Search for S. R. KRUGLIKOFF in:

About this article

Publication history




Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.