Abstract
INTRAPERITONEAL injections of catecholamines produce a marked depression of the psychomotor activity of mice, accompanied by vegetative phenomena, such as tachycardia, exophthalmos and pilo-erection. These vegetative phenomena are, however, independent of the psychomotor depression, for they can be suppressed by phentolamine (‘Regitin R’), an adrenergic blocking agent, without modifying the depressed behaviour. Furthermore, isopropylarterenol produced, in higher doses, a similar psychomotor depression, without vegetative symptoms1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fischer, E., and Amalfara, M. Lopez., Nature, 193, 590 (1962).
Rothballer, A. B., Pharmacol. Rev., 11, 794 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FISCHER, E., LUDMER, R. & KRUGLIKOFF, S. Effect of Methylamphetamine on the Psychomotor Depression produced by Adrenaline in Mice. Nature 204, 695–696 (1964). https://doi.org/10.1038/204695a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/204695a0
This article is cited by
-
Intergeneric behavioral differences among methamphetamine treated mice
Psychopharmacologia (1972)
-
Antagonistic Effects of Tryptamine and β-Phenylethylamine on the Behaviour of Rodents
Nature (1970)
-
Influence of Amino-oxidase Inhibitors on the Psychomotor Depression produced by an Intraperitoneal Injection of Adrenaline in Mice
Nature (1965)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
