Letter | Published:

Effect of Methylamphetamine on the Psychomotor Depression produced by Adrenaline in Mice

Nature volume 204, pages 695696 (14 November 1964) | Download Citation

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Abstract

INTRAPERITONEAL injections of catecholamines produce a marked depression of the psychomotor activity of mice, accompanied by vegetative phenomena, such as tachycardia, exophthalmos and pilo-erection. These vegetative phenomena are, however, independent of the psychomotor depression, for they can be suppressed by phentolamine (‘Regitin R’), an adrenergic blocking agent, without modifying the depressed behaviour. Furthermore, isopropylarterenol produced, in higher doses, a similar psychomotor depression, without vegetative symptoms1.

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References

  1. 1.

    , and , Nature, 193, 590 (1962).

  2. 2.

    , Pharmacol. Rev., 11, 794 (1959).

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  1. Laboratorio de Psicofarmacología y Neuropsiquiatría Experimental, Hospital Nacional de Neuropsiquiatría (H), Instituto Nacional de Salud Mental and Cátedra de Psiquiatría, Facultad de Ciencias Médicas, Universidad Nacional de Buenos Aires, Vieytes 375, Buenos Aires, Argentina.

    • E. FISCHER
    • , R. L. LUDMER
    •  & S. R. KRUGLIKOFF

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https://doi.org/10.1038/204695a0

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