Letter | Published:

A Selective Reagent for the Study of Base Sequence in Nucleic Acids

Nature volume 204, pages 685686 (14 November 1964) | Download Citation

Subjects

Abstract

SOME time ago, we proposed an electron microscopic procedure for the determination of the sequence of bases in nucleic acids1. This method requires that electron-dense, base-specific groups be attached to the nucleic acid molecule. On examination in the electron microscope, the visible electron-dense groups indicate the positions of those bases to which they are specifically attached.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , Proc. U.S. Nat. Acad. Sci., 48, 409 (1962).

Download references

Author information

Affiliations

  1. Departments of Biology and Biophysics, Johns Hopkins University, Baltimore 18, Maryland.

    • EVANGELOS N. MOUDRIANAKIS
    •  & MICHAEL BEER

Authors

  1. Search for EVANGELOS N. MOUDRIANAKIS in:

  2. Search for MICHAEL BEER in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/204685a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.