Letter | Published:

Effect of Amitosis on the Distribution of Human Lactic Acid Dehydrogenase Isozymes

Nature volume 204, pages 681682 (14 November 1964) | Download Citation

Subjects

Abstract

THE lactic acid dehydrogenase (LDH) of mammalian tissues exists as five isozymes1 which have different charges, structures and biochemical properties2. The pattern of isozyme distribution in embryonic and adult tissues indicates that the fertilized ovum also contains five isozymes5 which are identical to those of all other tissues3,4. In embryonic tissue isozyme III is the most abundant, but with cell differentiation the relative amount of isozyme III decreases (Table 1). There exists a parallel between the shift in isozyme distribution and the increase in cell nuclei population of human heart muscle. This increase (in the last phase through amitosis) comes to an end in the left heart muscle about six months after birth but is not finished even after one year in the right heart muscle6,8. It was, therefore, thought that the final distribution of isozymes would be achieved earlier in the muscle of the left heart ventricle than in the muscle of the right.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , Biochem. Z., 329, 112 (1957).

  2. 2.

    , and , Advances in Enzymology, edit. by Nord, F. F., 25, 329 (Interscience, New York, 1963).

  3. 3.

    , and , Biochem. Z., 336, 545 (1963).

  4. 4.

    , , and , Biochem. Z., 340, 80 (1964).

  5. 5.

    , and , Biochem. Z., 334, 185 (1961).

  6. 6.

    , in Handbuch der Allgemeinen Pathologie, 6, Part 1, 202 (Springer, Berlin, 1955).

  7. 7.

    , in Protoplasmatologia: Handbuch der Protoplasmaforschung, 6, E 1 (Springer, Berlin, 1959).

  8. 8.

    , Virchow's Archiv, 323, 223 (1953).

  9. 9.

    , , and , Enzymol. biol. clin., 2, 116 (1962/1963).

  10. 10.

    , and , Biochem. Biophys. Res. Comm., 6, 171 (1961).

  11. 11.

    , Science, 140, 1329 (1963).

  12. 12.

    , Klin. Wschr. (in the press).

Download references

Author information

Affiliations

  1. Biochemisches Institut der Universität, Frankfurt am Main, Germany.

    • E. D. WACHSMUTH

Authors

  1. Search for E. D. WACHSMUTH in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/204681b0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.