Abstract
THE lactic acid dehydrogenase (LDH) of mammalian tissues exists as five isozymes1 which have different charges, structures and biochemical properties2. The pattern of isozyme distribution in embryonic and adult tissues indicates that the fertilized ovum also contains five isozymes5 which are identical to those of all other tissues3,4. In embryonic tissue isozyme III is the most abundant, but with cell differentiation the relative amount of isozyme III decreases (Table 1). There exists a parallel between the shift in isozyme distribution and the increase in cell nuclei population of human heart muscle. This increase (in the last phase through amitosis) comes to an end in the left heart muscle about six months after birth but is not finished even after one year in the right heart muscle6,8. It was, therefore, thought that the final distribution of isozymes would be achieved earlier in the muscle of the left heart ventricle than in the muscle of the right.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wieland, Th., and Pfleiderer, G., Biochem. Z., 329, 112 (1957).
Wieland, Th., and Pfleiderer, G., Advances in Enzymology, edit. by Nord, F. F., 25, 329 (Interscience, New York, 1963).
Wachsmuth, E. D., and Pfleiderer, G., Biochem. Z., 336, 545 (1963).
Wachsmuth, E. D., Pfleiderer, G., and Wieland, Th., Biochem. Z., 340, 80 (1964).
Pfleiderer, G., and Wachsmuth, E. D., Biochem. Z., 334, 185 (1961).
Linzbach, A. J., in Handbuch der Allgemeinen Pathologie, 6, Part 1, 202 (Springer, Berlin, 1955).
Bucher, O., in Protoplasmatologia: Handbuch der Protoplasmaforschung, 6, E 1 (Springer, Berlin, 1959).
Hort, W., Virchow's Archiv, 323, 223 (1953).
Dioguardi, N., Agostini, A., and Fiorelli, G., Enzymol. biol. clin., 2, 116 (1962/1963).
Appella, E., and Markert, C. L., Biochem. Biophys. Res. Comm., 6, 171 (1961).
Markert, C. L., Science, 140, 1329 (1963).
Wachsmuth, E. D., Klin. Wschr. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WACHSMUTH, E. Effect of Amitosis on the Distribution of Human Lactic Acid Dehydrogenase Isozymes. Nature 204, 681–682 (1964). https://doi.org/10.1038/204681b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/204681b0
This article is cited by
-
Cell-marker studies in CLL with monoclonal OKT antisera and lactic dehydrogenase isoenzyme analysis
Blut (1983)
-
The differentiation of proximal and distal tubules in the male rat kidney: The appearance of aldolase isozymes, aminopeptidase and alkaline phosphatase during ontogeny
Histochemistry (1976)
-
Wirkung von Ploidiestufen auf die Differenzierung von Enzymen am Beispiel der Lactatdehydrogenase-Isozyme des Menschen
Klinische Wochenschrift (1965)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
