Letter | Published:

Rabbit Gamma-globulin Allotypes

Nature volume 204, pages 595596 (07 November 1964) | Download Citation



ALLOTYPIC specificity of rabbit γ-globulins differentiating individuals of the same species, was first described by Oudin1. This kind of specificity is defined by means of reactions between rabbit iso-precipitating sera and the serum of individuals of the same species. The iso-precipitating rabbit sera used for differentiating rabbit γ-globulins were obtained in two ways: (1) by injecting rabbits with immune complexes composed of heterologous antigen (human, equine, sheep and hen erythrocytes) and their corresponding rabbit immune antibodies; (2) by injecting rabbit with suspensions of rabbit globulins obtained by precipitation with aluminium potassium sulphate. In both cases it was necessary to take into account differences in γ-globulin characteristics between the rabbit donor of hetero-agglutinins or globulins and the rabbit donor of iso-precipitins.

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    , C.R. Acad. Sci., Paris, 242, 2608 (1956).

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    , Folia Biol., 10, 179 (1962).

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  1. Department of Blood Groups, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.



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