Abstract
ALLOTYPIC specificity of rabbit γ-globulins differentiating individuals of the same species, was first described by Oudin1. This kind of specificity is defined by means of reactions between rabbit iso-precipitating sera and the serum of individuals of the same species. The iso-precipitating rabbit sera used for differentiating rabbit γ-globulins were obtained in two ways: (1) by injecting rabbits with immune complexes composed of heterologous antigen (human, equine, sheep and hen erythrocytes) and their corresponding rabbit immune antibodies; (2) by injecting rabbit with suspensions of rabbit globulins obtained by precipitation with aluminium potassium sulphate. In both cases it was necessary to take into account differences in γ-globulin characteristics between the rabbit donor of hetero-agglutinins or globulins and the rabbit donor of iso-precipitins.
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References
Oudin, J., C.R. Acad. Sci., Paris, 242, 2608 (1956).
Grodecka, U., Folia Biol., 10, 179 (1962).
Dray, S., Dubiski, S., Kelus, A., Lennox, E. S., and Oudin, J., Nature, 195, 785 (1962).
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GRODECKA, U. Rabbit Gamma-globulin Allotypes. Nature 204, 595–596 (1964). https://doi.org/10.1038/204595a0
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DOI: https://doi.org/10.1038/204595a0
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