Abstract
THE experiments reported by Carey and Conway1 and by Conway2 on skeletal muscle, and by Hodgkin and Keynes3 on nerve fibre, show that ionic exchanges, especially sodium and potassium transfer, are related to aerobic metabolism in the living tissue. Therefore, metabolic inhibitors such as cyanides modify these exchanges between cell and surrounding medium by decreasing Na+ efflux and K+ influx.
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References
Carey, M. J., and Conway, E. J., Biochem. J., 64, 41P (1956).
Conway, E. J., Physiol. Rev., 37, 84 (1957).
Hodgkin, A. K., and Keynes, R. D., J. Physiol., 128, 28 (1955).
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VALETTE, G., OZAN, K. Action of Enzymatic Inhibitors (Potassium Cyanide and Sodium Fluoride) on Muscle Fibre Sensitivity to Potassium Ion. Nature 204, 586–587 (1964). https://doi.org/10.1038/204586a0
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DOI: https://doi.org/10.1038/204586a0
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