Letter | Published:

Ovarian Ascorbic Acid Depleting Activity in Human Brain Extracts

Nature volume 204, pages 583584 (07 November 1964) | Download Citation

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Abstract

IT has been established that the hypothalamus controls the secretion of luteinizing hormone (LH) of the adenohypophysis through a luteinizing hormone releasing factor (LH–RF)1,2. This substance occurs only in the stalk median eminence of the hypothalamus3,4 and, according to the literature, not in other brain tissue. Johnson5 has shown that the whole brain, the hypothalamus excluded, also contains a substance displaying characteristics proper to LH–RF.

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References

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    Harris, G. W. (edit.), The Nervous Control of the Pituitary Gland (Arnold, London, 1955).

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    , , and , Fed. Proc., 19, 292 (1960).

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    , , and , Proc. Soc. Exp. Biol. and Med., 104, 432 (1960).

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    , Amer. J. Physiol., 202, 395 (1962).

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    , Endocrinology, 72, 832 (1963).

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    , Fed. Proc., 17, 402 (1958).

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    , in Human Pituitary Gonadotropins, edit. by Albert, A., 301 (Charles Thomas, 1961).

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    , New Eng. J. Med., 257, 919 (1957).

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    , and , Endocrinology, 73, 193 (1963).

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Author information

Affiliations

  1. Laboratorio de Fisiologia, Facultad de Medicina, Universidad Católica, Chile.

    • M. DE LA LASTRA
    •  & HÉCTOR CROXATTO

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DOI

https://doi.org/10.1038/204583a0

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