Abstract
FROM the degradative investigations of Suzuki et al.1, and finally by its synthesis2, the structure of polymyxin B1 has now been established as (I): (R = (+)-6-methyloctanoyl, X = D-Phe), in which each of the six αγ-diaminobutyric acid units is of the L-configuration1,3. Suzuki et al.4 have also shown that the structure of colistin A is identical with that of polymyxin B1, except that the D-Phe in the latter is replaced by D-Leu (that is, 1; R = (+)-6-methyloctanoyl, X = D-Leu).
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Suzuki, T., Hayashi, K., Fujikawa, K., and Tsukamato, K., J. Biochem., (Japan), 54, 555 (1963).
Vogler, K., Studer, R. O., Lanz, P., Lergier, W., and Böhni, E., Experientia, 20, 365 (1964).
Wilkinson, S., and Lowe, L. A., Nature, 202, 1211 (1964).
Suzuki, T., Inouye, H., Fujikawa, K., and Suzeka, Y., J. Biochem. (Japan), 54, 25 (1963). Suzuki, T., Inouye, H., Fujikawa, K., and Nagasawa, S., ibid., 54, 173 (1963). Suzuki, T., Hayashi, K., and Fujikawa, K., ibid., 54, 414 (1963).
Wilkinson, S., and Lowe, L. A., J. Chem. Soc. (in the press).
Vogler, K., Studer, R. O., Lanz, P., Lergier, W., Böhni, E., and Fust, B., Helv. Chim. Acta., 46, 2824 (1963).
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WILKINSON, S., LOWE, L. Structures of Polymyxin B2 and Polymyxin E1. Nature 204, 185 (1964). https://doi.org/10.1038/204185a0
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DOI: https://doi.org/10.1038/204185a0
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Structures of Polymyxin B2 and Polymyxin E1
Nature (1964)
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