Abstract
IN recent years there has been considerable interest in the study of the chromosome complement of malignant tumours. In most of these investigations culture techniques have been utilized. Direct methods of study have an advantage in that there can be no questions of selection of particular clones that happen to proliferate better in in vitro conditions. Direct methods have worked well in examination of bone marrow and neoplastic effusions. However, study of solid neoplasms has been hampered by the fact that usually only a few metaphases suitable for karyotyping can be obtained from any given tumour.
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References
Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hunger-ford, D. A., Exp. Cell Res., 20, 613 (1960).
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ARVAN, D., ERB, W. & ENTERLINE, H. Sedimentation Rate of Cells in Metaphase as compared with Cells in Interphase. Nature 204, 1225–1226 (1964). https://doi.org/10.1038/2041225a0
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DOI: https://doi.org/10.1038/2041225a0
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