Abstract
THE structural alteration of mammalian hæmoglobin on ageing in vivo is evidenced by the accelerated electro-phoretic mobility of older hæmoglobin1 and its changed chromatographic behaviour2. Hybridization investigations have shown the variant chain in old hæmoglobin to be the β-chain3. A number of suggestions have been made as to the possible chemical nature of the modification4, the main one being that mixed disulphide formation with glutathione occurs5,6 as a consequence of the diminished enzyme activities present in older red blood cells.
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References
Kunkel, H. G., and Bearn, A. G., Fed. Proc., 16, 760 (1957).
Schapira, G., Labie, D., Rosa, J., and Dreyfus, J. C., Biochem. Biophys. Res. Comm., 9, 167 (1962).
Rosa, J., and Labie, D., Nature, 196, 901 (1962).
Walter, H., Nature, 198, 189 (1963).
Muller, C. J., thesis, Univ. Groningen (1961).
Allen, D. W., and Jandl, J. H., J. clin. Invest., 40, 454 (1961).
Prankerd, T. A. J., J. Physiol., 143, 325 (1958).
Walter, H., Selby, F. W., and Brake, J. M., Biochem. Biophys. Res. Comm., 15, 497 (1964).
Simon, E. R., and Topper, Y. J., Nature, 180, 1211 (1957).
Edwards, M. J., Koler, R. D., Rigas, D. A., and Pitcairn, D. M., J. Clin. Invest., 40, 636 (1961).
Walter, H., Biochim. Biophys. Acta, 69, 410 (1963).
Malcolm, D., Ranney, H. M., and Jacobs, A. S., Blood, 21, 8 (1963).
Ingram, V. M., The Haemoglobins in Genetics and Evolution, 148 (New York and London: Columbia Univ. Press, 1963).
Walter, H., Brake, J. M., and Selby, F. W., Exp. Cell Res. (in the press).
Walter, H., Biermann, L., and Sass, M. D., Exp. Cell Res., 27, 193 (1962).
Cooper, M., and Owen, C. A., J. Lab. Clin. Med., 47, 65 (1956).
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WALTER, H., SELBY, F. Chemical Reactivity of Avian and Mammalian Hæmoglobins of Different Ages. Nature 204, 1209–1210 (1964). https://doi.org/10.1038/2041209a0
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DOI: https://doi.org/10.1038/2041209a0
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