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Prevention of Fatty Liver by Administration of Adenosine Triphosphate

Abstract

IT has recently been shown that the fatty liver produced in rats by ethionine administration is associated with a decrease in hepatic adenosine triphosphate (ATP) levels and that injections of ATP are able to prevent both the fatty liver and the drop in ATP1,2. We have observed that a variety of agents which produce a fatty liver lead to decreased ATP concentrations in the liver and that the protective effects of ATP administration are not limited to ethionine toxicity.

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HYAMS, D., ISSELBACHER, K. Prevention of Fatty Liver by Administration of Adenosine Triphosphate. Nature 204, 1196–1197 (1964). https://doi.org/10.1038/2041196a0

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