Abstract
Ranney and Gluecksohn-Waelsch1 described in laboratory strains of the house mouse the hæmoglobin (Hb) types s = single and d = diffuse which differ in their electrophoretic behaviour. Of 20 inbred strains which were investigated six belonged to the ‘single’ (Hbs) and 14 to the ‘diffuse’ (Hbd) type2. In crosses Hbd is dominant over Hbs (ref. 3). Popp4,5 was able to localize the Hb-gene on chromosome I by discovering its linkage to the genes p, c and sh–1. In addition, there are differences in the solubility and peptide structure of the hæmoglobins within the Hbs and Hbd types which, as such, are differentiated by their electrophoretic patterns only4–7.
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References
Ranney, H. M., and Gluecksohn-Waelsch, S., Ann. Human Genetics, 19, 269 (1955).
Russell, E. S., and Gerald, P. S., Science, 128, 1569 (1958).
Gluecksohn-Waelsch, S., Ranney, H. M., and Sisken, B. F., J. Clin. Invest., 36, 753 (1957).
Popp, R., and Amand, W. S., J. Hered., 51, 141 (1960).
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Hutton, J. J., Bishop, J., Schweet, R., and Russell, E. S., Proc. U.S. Nat. Acad. Sci., Wash., 48, 1505 and 1718 (1962).
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Wagner, M., and Heinecke, H., Z. Versüchstiert. (in the press).
See Handbook on Genetically Standardized Jax Mice (Roscoe B. Jackson, Memorial Laboratory, Bar Harbor, Maine, 1962).
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HEINECKE, H., WAGNER, M. Hæmoglobin Types of the Wild House Mouse (Mus musculus domesticus Rutty 1772). Nature 204, 1099–1100 (1964). https://doi.org/10.1038/2041099a0
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DOI: https://doi.org/10.1038/2041099a0
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