Abstract
IT has recently been shown that the multiplication of many picornaviruses can be specifically inhibited by non-cytotoxic concentrations of guanidine hydrochloride and 2-(α-hydroxybenzyl)-benzimidazole (HBB)1. These inhibitors appear to act by interfering with the production of virus-induced RNA-polymerase2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tamm, I., and Eggers, H. J., Virology, 18, 439 (1963).
Baltimore, D., Eggers, H. J., Franklin, R. M., and Tamm, I., Proc. U.S. Nat. Acad. Sci., 49, 843 (1963).
Macpherson, I. A., and Stoker, M. G. P., Virology, 16, 147 (1962).
Martin, W. B., and Chapman, W. G., Res. Vet. Sci., 2, 53 (1961).
Sellers, R. F., Nature, 176, 547 (1955).
Brown, G. C., J. Immunol., 69, 441 (1952).
Subak-Sharpe, H., and Pringle, C. R. (in preparation).
Platt, H., J. Path. Bact., 72, 299 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PRINGLE, C. Inhibition of Multiplication of Foot-and-Mouth Disease Virus by Guanidine Hydrochloride. Nature 204, 1012–1013 (1964). https://doi.org/10.1038/2041012a0
Issue Date:
DOI: https://doi.org/10.1038/2041012a0
This article is cited by
-
Bovine, porcine and ovine picornaviruses: identification of viruses with properties similar to human coxsackieviruses
Archives of Virology (1987)
-
Further biochemical testing of feline picornaviruses
Archiv f�r die gesamte Virusforschung (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.