Abstract
THE presence of C-6 oxygenated steroids in neonatal urine was first reported by Ulstrom et al.1. It has been demonstrated2,3 that placental tissue incubated under standard conditions, is able to oxygenate at the C-6 position, while the work of Frantz et al.4 has indicated that during pregnancy the urinary concentrations of the polar steroid 6β-hydroxycortisol is elevated above the normal non-pregnant state. It appeared likely, therefore, that similar polar steroids might be present in liquor amnii.
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LAMBERT, M., PENNINGTON, G. Isolation and Identification of the 20β-Hydroxy Derivatives of 6β-Hydroxycortisol and 6β-Hydroxycortisone in Liquor Amnii. Nature 203, 656 (1964). https://doi.org/10.1038/203656a0
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DOI: https://doi.org/10.1038/203656a0
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