Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Potentiation of Virus Leukæmogenesis in C57BL Mice by X-irradiation or Urethane

Nature volume 203, pages 420–422 (1964)Cite this article

Abstract

LYMPHOID tumours can be induced in high incidence in strain C57BL mice by fractionated whole-body X-irradiation1. Urethane has also been shown to act as an independent leukæmogenic agent when administered to C51BL mice shortly after birth2. In adult mice, urethane acts as a co-leukæmogenic agent, potentiating the leukæmogenic effects of radiation or other carcinogenic agents, but exhibits little or no leukæmogenic activity when used alone3.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kaplan, H. S., and Brown, M. B., J. Nat. Cancer Inst., 13, 185 (1952).

    CAS  PubMed  Google Scholar 

  2. Doell, R. G., and Carnes, W. H., Nature, 194, 588 (1962).

    Article  ADS  CAS  Google Scholar 

  3. Kawamoto, S., Ida, N., Kirschbaum, A., and Taylor, G., Cancer Res., 18, 725 (1958); Berenblum, I., and Trainin, N., Science, 134, 2045 (1961).

    CAS  Google Scholar 

  4. Lieberman, M., and Kaplan, H. S., Science, 130, 387 (1959).

    Article  ADS  CAS  Google Scholar 

  5. Kaplan, H. S., Nat. Cancer Inst. Monograph (in the press).

  6. Law, L. W., and Dawe, C. J., Proc. Soc. Exp. Biol. and Med., 105, 414 (1960).

    Article  CAS  Google Scholar 

  7. Axelrad, A. A., and van der Gaag, H. C., Proc. Amer. Assoc. Cancer Res., 3, 301 (1962).

    Google Scholar 

  8. Jenkins, V. K., and Upton, A. C., Cancer Res., 23, 1748 (1963).

    CAS  PubMed  Google Scholar 

  9. Kaplan, H. S., Acta Unio Internat. Contra Cancrum, 17, 143 (1961).

    CAS  Google Scholar 

  10. Axelrad, A. A., and van der Gaag, H. C., J. Nat. Cancer Inst., 28, 1065 (1962).

    CAS  PubMed  Google Scholar 

  11. Law, L. W., and Precerutti, A., Nature, 200, 692 (1963).

    Article  ADS  CAS  Google Scholar 

  12. Haran-Ghera, N., and Kaplan, H. S. (submitted for publication).

Download references

Author information

Author notes

  1. NECHAMA HARAN-GHERA: Eleanor Roosevelt Foundation Fellow, 1963–64, on leave from the Weizmann Institute of Science, Rehovoth, Israel.

Authors and Affiliations

  1. Department of Radiology, Stanford University School of Medicine, Palo Alto, California

    MIRIAM LIEBERMAN, NECHAMA HARAN-GHERA & HENRY S. KAPLAN

Authors
  1. MIRIAM LIEBERMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. NECHAMA HARAN-GHERA
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. HENRY S. KAPLAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LIEBERMAN, M., HARAN-GHERA, N. & KAPLAN, H. Potentiation of Virus Leukæmogenesis in C57BL Mice by X-irradiation or Urethane. Nature 203, 420–422 (1964). https://doi.org/10.1038/203420b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/203420b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing