Abstract
THE metabolism of adipose tissue is remarkably sensitive to the action of a number of hormones1,2. Epinephrine and ACTH, for example, when added in low concentrations to incubated adipose tissue, stimulate the release of fatty acids3–5, and addition of insulin to the incubated tissue can inhibit its response to these lipolytic agents6. The mechanism of action of this hormonal control of adipose tissue metabolism is not known nor is it established that all the effects manifested in vitro have physiological significance.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Jeanrenaud, B., Metabolism, 10, 535 (1961).
Vaughan, M., J. Lipid Res., 2, 293 (1961).
Hollenberg, C. H., Raben, M. S., and Astwood, E. B., Endocrinology, 68, 589 (1961).
White, J. E., and Engel, F. L., J. Clin. Invest., 37, 1556 (1958).
Gordon, R. S., jun., and Cherkes, A., Proc. Soc. Exp. Biol. Med., 97, 150 (1958).
Jungas, R. L., and Ball, E. G., Biochem., 2, 383 (1963).
Korner, A., and Manchester, K. L., Brit. Med. Bull., 16, 233 (1960).
Manchester, K. L., and Young, F. G., Vitamins and Hormones, 19, 95 (1961).
Yarmolinsky, M. B., and de la Haba, G. L., Proc. U.S. Nat. Acad. Sci., 45, 1721 (1959).
Nathans, D., Proc. U.S. Nat. Acad. Sci., 51, 585 (1964).
Nathans, D., and Neidle, A., Nature, 197, 1076 (1963).
Hofert, J. F., and Boutwell, R. K., Arch. Biochem. Biophys., 103, 338 (1963).
Dole, V. P., J. Clin. Invest., 35, 150 (1956).
Fain, J. N. (personal communication).
Butcher, R. W., Ho, R. J., Meng, H. C., and Sutherland, E. W., Abst. Sixth Intern. Congr. Biochem., 9, 715 (1964).
Sutherland, E. W., Abst. Sixth Intern. Congr. Biochem., 9, 707 (1964).
Rizack, M. A., J. Biol. Chem., 239, 392 (1964).
Vaughan, M., J. Biol. Chem., 235, 3049 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KORNER, A., RABEN, M. Effect of Aminonucleoside and Puromycin on Insulin and Epinephrine Control of Fatty Acid Release from Adipose Tissue. Nature 203, 1287–1289 (1964). https://doi.org/10.1038/2031287a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/2031287a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.