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Effect of Aminonucleoside and Puromycin on Insulin and Epinephrine Control of Fatty Acid Release from Adipose Tissue

Abstract

THE metabolism of adipose tissue is remarkably sensitive to the action of a number of hormones1,2. Epinephrine and ACTH, for example, when added in low concentrations to incubated adipose tissue, stimulate the release of fatty acids3–5, and addition of insulin to the incubated tissue can inhibit its response to these lipolytic agents6. The mechanism of action of this hormonal control of adipose tissue metabolism is not known nor is it established that all the effects manifested in vitro have physiological significance.

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References

  1. Jeanrenaud, B., Metabolism, 10, 535 (1961).

    CAS  PubMed  Google Scholar 

  2. Vaughan, M., J. Lipid Res., 2, 293 (1961).

    CAS  Google Scholar 

  3. Hollenberg, C. H., Raben, M. S., and Astwood, E. B., Endocrinology, 68, 589 (1961).

    Article  CAS  Google Scholar 

  4. White, J. E., and Engel, F. L., J. Clin. Invest., 37, 1556 (1958).

    Article  CAS  Google Scholar 

  5. Gordon, R. S., jun., and Cherkes, A., Proc. Soc. Exp. Biol. Med., 97, 150 (1958).

    Article  CAS  Google Scholar 

  6. Jungas, R. L., and Ball, E. G., Biochem., 2, 383 (1963).

    Article  CAS  Google Scholar 

  7. Korner, A., and Manchester, K. L., Brit. Med. Bull., 16, 233 (1960).

    Article  CAS  Google Scholar 

  8. Manchester, K. L., and Young, F. G., Vitamins and Hormones, 19, 95 (1961).

    Article  CAS  Google Scholar 

  9. Yarmolinsky, M. B., and de la Haba, G. L., Proc. U.S. Nat. Acad. Sci., 45, 1721 (1959).

    Article  CAS  ADS  Google Scholar 

  10. Nathans, D., Proc. U.S. Nat. Acad. Sci., 51, 585 (1964).

    Article  CAS  ADS  Google Scholar 

  11. Nathans, D., and Neidle, A., Nature, 197, 1076 (1963).

    Article  CAS  ADS  Google Scholar 

  12. Hofert, J. F., and Boutwell, R. K., Arch. Biochem. Biophys., 103, 338 (1963).

    Article  CAS  Google Scholar 

  13. Dole, V. P., J. Clin. Invest., 35, 150 (1956).

    Article  CAS  Google Scholar 

  14. Fain, J. N. (personal communication).

  15. Butcher, R. W., Ho, R. J., Meng, H. C., and Sutherland, E. W., Abst. Sixth Intern. Congr. Biochem., 9, 715 (1964).

    Google Scholar 

  16. Sutherland, E. W., Abst. Sixth Intern. Congr. Biochem., 9, 707 (1964).

    Google Scholar 

  17. Rizack, M. A., J. Biol. Chem., 239, 392 (1964).

    CAS  PubMed  Google Scholar 

  18. Vaughan, M., J. Biol. Chem., 235, 3049 (1960).

    CAS  PubMed  Google Scholar 

Download references

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KORNER, A., RABEN, M. Effect of Aminonucleoside and Puromycin on Insulin and Epinephrine Control of Fatty Acid Release from Adipose Tissue. Nature 203, 1287–1289 (1964). https://doi.org/10.1038/2031287a0

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