Abstract
DURING the previous investigations1 in this laboratory human myometrial strips were exposed to progesterone until all spontaneous activity ceased and the changes in the concentration of adenosine triphosphate (ATP) and phosphocreatine (PC) measured. Until such paralysis had existed for at least 40 min, no significant change in high-energy phosphate bonds (ATP and PC) could be documented. It was, therefore, concluded that in the earlier stages of the myometrial inhibition progesterone might be exerting its effect in the utilization of ATP rather than in its synthesis. As a continuation of the investigations on this problem, the effect of progesterone was then determined on the ATPase activity of the human myometrial strips. This communication deals with the results obtained.
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References
Kumar, D., and Barnes, A. C., Bull. Johns Hopkins Hosp., 113, 330 (1963).
DuBois, K. P., and Potter, V. R., J. Biol. Chem., 150, 185 (1943).
Rockstein, M., and Herron, P. W., Anal. Chem., 23, 1500 (1951).
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KUMAR, D., ADAMS, P. & BARNES, A. Inhibitory Effect of Progesterone on Activity of Human Myometrial Adenosine Triphosphatase. Nature 203, 83 (1964). https://doi.org/10.1038/203083a0
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DOI: https://doi.org/10.1038/203083a0
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